What time of day should I take zinc and magnesium?

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Finding the right time to take supplements can make a significant difference in how effectively they work within our bodies. Two essential minerals that often go hand in hand when it comes to supplementation are zinc and magnesium. These minerals play crucial roles in various bodily functions and have been associated with numerous health benefits. In this blog post, we will delve into the question of when is the best time to take zinc and magnesium supplements. By exploring the effects of timing on absorption, interaction with other substances, and circadian rhythms, we aim to provide you with valuable insights to maximize the benefits of these vital minerals.

What time of day should i take zinc and magnesium?

The Absorption Puzzle: Morning or Evening?

  1. Zinc and magnesium are both absorbed through the small intestine, but they have different characteristics that can influence their absorption rates. The timing of their consumption can affect how efficiently our bodies take in these minerals. Let’s explore whether morning or evening intake is more favorable for each mineral.


Zinc is commonly found in various foods and is essential for supporting our immune system, DNA synthesis, and protein metabolism. When it comes to timing, taking zinc supplements in the morning may offer some advantages. Our bodies tend to have higher zinc levels in the morning, making it an optimal time for absorption. Additionally, consuming zinc in the morning allows it to be available during the day when immune functions are most active. However, it’s crucial to consider other factors such as medication interactions and the potential for an empty stomach, which may cause gastrointestinal discomfort. Therefore, it’s advisable to consult with a healthcare professional to determine the best timing for zinc supplementation that suits your specific needs.


Magnesium, on the other hand, is involved in over 300 enzymatic reactions in the body and plays a vital role in muscle and nerve function, energy production, and bone health. While the timing of magnesium intake can vary depending on the individual, there are a few considerations to keep in mind. Many people find that taking magnesium supplements in the evening promotes relaxation and supports a night of restful sleep. Magnesium has a natural calming effect and can help regulate the body’s stress response. Furthermore, magnesium can enhance the production of melatonin, a hormone that regulates sleep-wake cycles. However, it’s important to be mindful of potential interactions with other medications, as some may interfere with magnesium absorption. Again, consulting with a healthcare professional can help determine the best timing for magnesium supplementation based on your specific circumstances.

Synergistic or Antagonistic: Interactions with Food and Other Supplements

The effectiveness of zinc and magnesium supplements can be influenced by interactions with other substances, including food and other supplements. Understanding these interactions is crucial for optimizing the benefits derived from their supplementation. Let’s explore the interplay between zinc, magnesium, and these external factors.

Food Interactions:

Consuming food alongside zinc and magnesium supplements can influence their absorption and potential side effects. For zinc, taking it on an empty stomach can increase the risk of gastrointestinal discomfort, including nausea and stomach cramps. Therefore, it’s generally recommended to take zinc with food to enhance its absorption and reduce the likelihood of digestive issues. On the other hand, magnesium can be taken with or without food, as it is well-tolerated in most individuals. However, some people may experience loose stools when taking higher doses of magnesium, in which case dividing the dosage throughout the day or taking it with meals can help minimize this effect.

Supplement Interactions:

Zinc and magnesium can interact with other supplements, potentially affecting their absorption or efficacy. For example, calcium and iron can compete with zinc for absorption, so it’s advisable to separate the intake of these minerals. Taking zinc and iron supplements at least two hours apart can prevent their interference with each other’s absorption. Conversely, magnesium can enhance calcium absorption and is often combined with calcium supplements to maximize its benefits. However, it’s important to maintain appropriate ratios and consult a healthcare professional to ensure optimal absorption and avoid potential adverse effects.

By understanding the intricate interactions between zinc, magnesium, and external factors, you can make informed decisions about the timing and combination of these minerals, ultimately maximizing their potential benefits for your overall well-being.

The Rhythm of the Body: Considering Circadian Influences

The human body operates on a natural circadian rhythm, a biological clock that regulates various physiological processes over a 24-hour cycle. The timing of zinc and magnesium supplementation can take advantage of this internal rhythm to optimize their absorption and utilization. Let’s explore how circadian influences may affect these minerals.

Zinc and Circadian Rhythms:

Research suggests that zinc levels follow a diurnal pattern, with higher concentrations in the morning and lower levels in the evening. As previously mentioned, taking zinc supplements in the morning aligns with this natural rhythm, potentially enhancing its absorption and utilization within the body. Moreover, our immune functions tend to be more active during the day, making morning zinc intake a strategic choice for supporting immune health. However, individual variations and specific health conditions should be considered, as they may affect the ideal timing for zinc supplementation.

Magnesium and Circadian Rhythms:

The circadian rhythm also plays a role in magnesium metabolism. The mineral’s levels tend to fluctuate throughout the day, with the lowest concentrations typically observed in the early morning. This natural variation suggests that taking magnesium in the evening, particularly before bed, can help optimize its absorption and promote relaxation for a restful sleep. By aligning magnesium supplementation with the body’s natural rhythms, you may harness its calming effects and support overall sleep quality. However, individual variations, potential interactions with medications, and personal sleep habits should be taken into account when determining the optimal timing for magnesium intake.


By carefully considering the absorption characteristics, interactions with food and supplements, and circadian influences, you can make informed decisions about the optimal timing for zinc and magnesium supplementation. Remember to consult with a healthcare professional to tailor these recommendations to your unique circumstances and achieve the maximum benefits from these essential minerals. Harnessing the power of timing can unlock the full potential of zinc and magnesium, supporting your overall health and well-being.

What time of day should I take zinc and magnesium?
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